當(dāng)前位置:首頁(yè) > 產(chǎn)品中心 > 抗體/抗原 > 一抗 > bsm-62661R磷酸化雙微體2癌基因重組兔單抗
簡(jiǎn)要描述:Inhibits TP53/p53- and TP73/p73-mediated cell cyclearrest and apoptosis by binding its transcriptional activation domain. Functions as a ubiquitin ligase E3, in the presence of E1 and E2, toward p53 and itself. Permits the nuclear export of p53 and targets it for proteasome-mediated proteolysis. Binds p53, p73, ARF(P14), ribosomal protein L5 and specifically to RNA. Can interact also with retinoblastoma protein(RB), E1A-associated protein EP300 and the E2F1 transcription factor. Forms a
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